Regenaflex-K9 is an intra-muscular injectable that provides unparalleled convenience to small- and mixed-animal veterinary practices. 

The Hilltop Bio Difference

Compared to older orthobiologics like PRP or stem cells that are variable, labor-intensive, and require special equipment, our therapies are consistent dose-to-dose and are ready to use in under a minute!

One-Step Prep: Ready to use in under a minute

No Variability: Consistent formulation delivers reliable results

100% Natural: Avoid the risks associated with pharmaceuticals or steroids

Save Time & Money: no equipment or processing required

Off-the-Shelf: Long-term, room temperature storage

Quality: Manufactured under strict cGMP/cGTP guidelines

Uses

  • Non-healing wounds
  • Lameness associated with soft tissue injury (tendon, ligament, muscle)
  • Lameness secondary to osteoarthritis

Studies

  • Osteoarthritis: Hilltop Bio recently completed a blinded study using Regenaflex-K9 for Canine Osteoarthritis. Preliminary data looks positive and we expect to publish results this fall.
  • Read our Regenaflex Safety Study.

How Does Regenaflex-K9 Work?

Regenaflex-K9 contains growth factors, cytokines, and exosomes — factors demonstrated to stimulate healing by delivering a cell-signaling cascade to reduce inflammation, promote healing, and decrease scarring.

Case Study

Dr. Peggy Minnich  | Aquia-Garrisonville Animal Hospital

Shiloh is a 125lb, 6yo neutered male shepherd

  • Lame in the left front leg for about a year, receiving only joint supplements. Pain was localized to the shoulder joint at the insertion point of the biceps tendon.

IMAGING: No bony abnormalities were noted.

TREATMENT: Shock Wave therapy was administered on the joint, resulting in about 70% improvement. Shiloh then received one 1ml dose of Regenaflex-K9.

RESULTS: 2 weeks after this injection, he was 100% sound.

References:

  1. Dinarello CA. Historical review of cytokines. Eur J Immunol 2007;37(Suppl1):S35-S45.
  2. Gelhorn A and Han A. The use of dehydrated human amnion/chorion membrane allograft injection for the treatment of tendinopathy or arthritis: A case series involving 40 patients. P M & R 2017;9:1236-1243.
  3. Gulati K, Guhathakurta S, Joshi J, et al. Cytokines and their role in health and disease: a brief overview. MOJ Immunol 2016;4(2):00121.
  4. Gupta A. Allogenic Amniotic Tissue for Treatment of Knee and Hip Osteoarthritis. Pharmaceuticals (Basel). 2022 Mar 26;15(4):404.
  5. Kimmerling, K.A., Gomoll, A.H., Farr, J. et al. Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model. Arthritis Res Ther 24, 63 (2022).
  6. Shimberg, M. The use of amniotic-fluid concentrate in orthopedic conditions. Journal of Bone and Joint Surgery, Vol. 20 No. 1, January 1938. 
  7. Werber, B. Amniotic tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis. Journal of Sports Medicine 215, 219896, 2015.
  8. Williams, K. B., & Ehrhart, N. P. Regenerative medicine 2.0: extracellular vesicle–based therapeutics for musculoskeletal tissue regeneration. JAVMA, 2022; 260(7), 683-689.