Left: taken 8/10/2021 before treatment. Right: taken 9/16/2021 after treatment.

A 1300 lb Paint gelding named “Goose” used for competitive trail and halter presented on May 7, 2020 for a 4/5 lameness on the RF with marked swelling of the palmar proximal metacarpus.

EXAM FINDINGS

Ultrasound examination showed a diffuse anechoic to hypoechoic disruption of the inferior check ligament from zones 1A through 2A.

TREATMENT

Goose was stall rested and was placed in a cold salt water spa twice daily for one week. NSAIDS were not administered.

Regenaflex was injected via ultrasound guidance into the anechoic portion of the disruption on May 14, 2020. 

Hand walking was initiated daily once he was comfortable moving at a walk. RLT laser therapy was performed twice a week for 4 weeks following the amnion injection.

On June 25^th Goose had improved to a slight lameness in a straight line trot on the RF limb and aquatread exercise was initiated twice weekly for 2 weeks and then increased to 3 times weekly.

On July 30^th Goose was sound and ultrasound of the inferior check ligament showed significant healing and organization. Goose was placed into controlled exercise in saddle with a gradual increase in work.

He has been shown successfully multiple times since July and remains sound.

19 year old pony treated only with Regenaflex-RT.

Client Constraints: able to do only one treatment with no adjunctive treatments.

All therapies were considered: PRP, stem cells, shockwave, laser, etc. With primary considerations being effectiveness and risk of causing more damage, Regenaflex was decided on as the best choice.

Treatment: Early Feb 2022 – 1 dose of Regenaflex; no other treatments.

Post Treatment: Hand-walked for 30 days and then turned out in a small paddock.

See video for full details.

Results: Rechecked at the beginning of August 2022 and was shocked by new scan. The leg had no profile to it, the lesion had filled in really nicely, the fiber pattern was pretty uniform with the rest of the tendon.

“This was kind of a slam dunk case… We were pessimistic about the long-term prognosis given the pony’s age. This case study really sold me on the product because it was such a positive result in a case that probably shouldn’t have had such good results.“

Treated with Regenaflex-M membrane by Dr. Emily Hood of Hood Equine. 

Day 0

Day 14

Day 30

Day 166

Dr. Laurie Goodrich of Colorado State University treated a severe wound of the forelimb pastern and below with Regenaflex-M membrane.

July 6

July 9

July 17

July 26

Regenaflex-M Application

August 18

September 23 and October 5

Dr. Kevin Voller of Anoka Equine treated a draining coronary band with debridement. On Feb 24, 2022, several weeks post initial injury, a Regenaflex-M membrane was placed on the wound. On Day 14 post membrane placement, a Regional Limb Perfusion was performed using Regenaflex-RT. The hoof continued to improve and fill in.

Feb 24, 2022

Mar 19, 2022

Jun 24, 2022

Sep 1, 2022

Dr Marty Tanner of Tanner Equine treated a wound that had previously not healed after several weeks of bandage changes and standard-of-care treatment. The wound was later treated with Regenaflex-M membrane and saw results in 3 weeks.

Treated with Regenaflex-Gel.

DAY 0

At 8 WEEKS

PureOptic administered via sub palpable lavage (SPL).

DAY 0 (8/16/2023)

DAY 5 (8/21/2023)

Treated with PureOptic.

Shiloh is a 6 year old neutered male shepherd weighing 125 pounds. He was lame in the left front leg for about a year before coming to me. Owner had placed him on joint supplements only.  Pain was localized to the shoulder joint at the insertion point of the biceps tendon. Given his giant breed status, ruling out osteosarcoma was very important, so radiographs were taken, and no bony abnormalities were noted.

We do not have access to ultrasound, so proceeded with Shock Wave therapy on the shoulder joint.  Shiloh was about 70% improved but because of severe anxiety with car rides, the owner did not want to bring him back up to the clinic, so I went to her farm and gave the 1 ml dosage of the [Regenaflex-K9] for dogs. 2 weeks after this injection, he is 100% sound.

See Before-and-After video below.

⋅Dr Tony Rodriguez of Foxfield Veterinary Services, Downington, PA.

Chumlee: 11-year-old, Male neutered, Shar Pei canine

History & Treatment

Chumlee presented on 1/25/22 after experiencing an acute traumatic lesion to a large sternal mass. The mass was removed, and the site closed under extensive tension. Chumlee returned 1/31/22 for evaluation due to incisional dehiscence. The skin was necrotic and infected thus extensive debridement was required resulting in a large open wound. The resulting wound was approximately 4.5inches (110cm)². Regenaflex-M was applied on 2/5/22 and a bandage applied.

Post-Treatment Evaluations

2/14/22: Resulted in wound contracture and healing. The site was debrided, scrubbed and silver sulfadiazine applied along with a soft bandage. The wound was approximately 70cm².

2/21/22: The above procedure was repeated. Approximate wound size was 50cm².

3/1/22: The above procedure was repeated. Approximate wound size was 30cm².

3/7/22: The above procedure was repeated. Approximate wound size was 15cm². At this point the would was small enough to be left unbandaged and the owner was instructed to manage the remaining care at home.

Conclusion

The application of Regenaflex-M appears to have greatly improved the healing time of a large wound and aided in second intention healing. Approximately 20cm of wound contracture/healing was noted weekly.

On 11/16/21 Eva was attacked by a larger dog while on a walk.  

11/16/21 – temp – 100.5 

• Wounds on left lateral aspect flank/dorsal rump. Referred to ER clinic for radiographs and wound care for moderate locally extensive soft tissue swelling & emphysema to left lateral flank. No evidence of penetration of abdominal cavity.  Wounds are deep and a large pocket ventrally 2-3” from puncture wounds. Large pocket on dorsal flank 4-5”.  

11/17/21 – temp – 103.7

• Large amount of serous/bloody discharge. Changed bandage. Started on orbax and gabapentin

11/18/21 – temp – 101.1

• Bandage change. Removed penrose drains and flushed with sterile saline. 

11/22/21

• Dehiscence from sutures. Brown, thick mucopurulent discharge from drain openings. Neutropenia, azotemia. IV catheter placed, started on baytril IV. Surgical explore – debrided wound, trimmed necrotic tissue. Packed wound with sterile saline gauze and placed a tie-over bandage over wound. 

11/23/21 – temp 101.7

• Unasyn IV, baytril IV. Flushed wound and repacked with sterile saline gauze and placed a tie-over bandage over wound

11/24/21 – temp 100.6 

• Unasyn IV, baytril IV. Sedate and removed saline gauze pads. Flushed with sterile saline. Applied amniotic membrane graft [Regenaflex-M]. Debrided wound edges and closed w/ 2-0 PDS. Started on clamox. 

Further visits showed continued improvement with full resolution by the end of December.

⋅Treated with Regenaflex-Gel

“Gryff”

Aug 24

Sep 5

Sep 7