Williams, K. B., & Ehrhart, N. P. Regenerative medicine 2.0: extracellular vesicle–based therapeutics for musculoskeletal tissue regeneration. JAVMA, 2022; 260(7), 683-689.
Kulebyakin K, Nimiritsky P, Makarevich P. Growth factors in regeneration and regenerative medicine: “the cure and the cause.” Front Endocrinol 2020;11:384.
Ren X, Zhao M, Lash B, et al. Growth factor engineering strategies for regenerative medicine applications. Front Bioeng Biotech 2020:7:469.
Gulati K, Guhathakurta S, Joshi J, et al. Cytokines and their role in health and disease: a brief overview. MOJ Immunol 2016;4(2):00121.
Farahani R, Sherkat R, Hakemi MG, Eskandari N, Yazdani R. Cytokines (interleukin-9, IL-17, IL-22, IL-25, and IL-33) and asthma. Adv Biomed Res 2014;3:127-133.
Mosser DM and Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev 2008;226:205-218.
Dinarello CA. Historical review of cytokines. Eur J Immunol 2007;37(Suppl1):S35-S45.
Caplan A and Dennis J. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98:1076-1084.
Waltenberger J. Modulation of growth factor action. Circulation 1997;96:4083-4094.
Orthopedic Conditions
Kimmerling, K.A., Gomoll, A.H., Farr, J. et al. Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model. Arthritis Res Ther 24, 63 (2022).
Gupta A. Allogenic Amniotic Tissue for Treatment of Knee and Hip Osteoarthritis. Pharmaceuticals (Basel). 2022 Mar 26;15(4):404.
Orlandin JR, Gomes IDS, Sallum Leandro SF, Fuertes Cagnim A, Casals JB, Carregaro AB, Freitas SH, Machado LC, Reis Castiglioni MC, Garcia Alves AL, de Vasconcelos Machado VM, Ambrósio CE. Treatment of Chronic Spinal Cord Injury in Dogs Using Amniotic Membrane-Derived Stem Cells: Preliminary Results. Stem Cells Cloning. 2021 Oct 18;14:39-49.
Gelhorn A and Han A. The use of dehydrated human amnion/chorion membrane allograft injection for the treatment of tendinopathy or arthritis: A case series involving 40 patients. P M & R 2017;9:1236-1243.
Lei J, Priddy l, Lim J, et al. Dehydrated human amnion/chorion membrane (dHACM) allografts as therapy for orthopedic tissue repair. Tech Orthop 2017;32:149-157.
Werber, B. Amniotic tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis. Journal of Sports Medicine 215, 219896, 2015.
Lange-Consiglio A, Tassan S, Corradetti B, Meucci A, Perego R, Bizzaro D, Cremonesi F. Investigating the efficacy of amnion-derived compared with bone-marrow-derived mesenchymal stromal cells in equine tendon and ligament injuries. Cytotherapy, 2013; 0, 1-10.
Meng, H; Li, M; You; F; Du, J; Luo, Z. Assessment of processed human amniotic membrane as a protective barrier in rat model of sciatic nerve injury. Neuroscience Letters, 496 (2011), 48-53.
OrthoInfo. Helping Fractures Heal (Orthobiologics). January 2010. Available at: https://orthoinfo.aaos.org/en/treatment/helping-fractures-heal-orthobiologics/
Shimberg, M. The use of amniotic-fluid concentrate in orthopedic conditions. Journal of Bone and Joint Surgery, Vol. 20 No. 1, January 1938.
Ophthalmic Conditions
Costa, Daniel et al. “A multicenter retrospective study on cryopreserved amniotic membrane transplantation for the treatment of complicated corneal ulcers in the dog.” eVeterinary ophthalmology vol. 22,5 (2019): 695-702.
Henriksen, M de Linde et al. “Visual outcome after corneal transplantation for corneal perforation and iris prolapse in 37 horses: 1998-2010.” Equine veterinary journal. Supplement ,43 (2012): 115-9.
Plummer, C. The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008). Vet Ophthal, 2009(12), Supplement, 17-24.
Lassaline, Mary E et al. “Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses.” Veterinary ophthalmology vol. 8,5 (2005): 311-7.
Kubo M, Sonoda Y, Muramatsu R, et al. Immunogenicity of human amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Visual Sci 2001;42:1539-1546.
Amniotic Membrane
Farhadihosseinabadi B, Farahani M, Tayebi T, et al. Amniotic membrane and its epithelial and mesenchymal stem cells as an appropriate source for skin tissue engineering and regenerative medicine. Artificial Cells Nanomed Biotech 2018;46:431-440.
DiDomenico LA, Orgill DP, Galiano RD, et al. Use of an aseptically processed, dehydrated human amnion and chorion membrane improves likelihood and rate of healing in chronic diabetic foot ulcers: A prospective, randomised, multi-centre clinical trial in 80 patients. Int Wound J. 2018;15:950–957.
Galera, PD, Ribiero CR, Sapp HL, et al. Proteomic analysis of equine amniotic membrane: characterization of proteins. Vet Ophthalmol 2014;18:1-12.
Najibpour, N; Jahantab, MB; Josseinzadeh, M; et al. The effects of human amniotic membrane on healing of colonic anastomosis in dogs. Ann Colorectal Res 2013;1(3):97-100.
Koob TJ, Rennert R, Zabek N, et al. Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int Wound J 2013;10:493–500.
Davis J. Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital. Johns Hopkins Med J 1910;15:307-396.
Other Regenerative Therapy Products
Mazzocca A, McCarthy M, Chowaniec D, et al. Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg 2012; 94:308-316.
