[Researchers] actually found in this study that the concentration of exosomes was directly related to healing. And we know there’s a high concentration of exosomes present [in Hilltop Bio therapies].
– Dr. Scott McClure, DVM, PhD, Dipl. ACVS, ACVSMR | watch the webinar
Hilltop Bio’s regenerative therapies rely on the wide array of components produced by amniotic cells—including cytokines, growth factors, exosomes, and other proteins—that work together naturally to boost tissue healing.
Among many other benefits, these components have demonstrated the ability to:
- Reduce pain, scarring and inflammation
- Promote blood flow
- Enhance tissue healing
- Possess antimicrobial properties
By analyzing the effects of the various components, we’ve been able to develop individual therapies that are optimized for specific uses. This means that the formulation of our joint therapy differs from that of our soft tissue therapy, etc.
The introduction of one of our proprietary mixes into or around damaged tissue initiates a cell-signaling cascade that draws added healing components to the area while helping to minimize both inflammation and scarring.
The Science
Hilltop Bio has conducted extensive proteomic research, cytokine and exosome characterizations, and translational science to better understand how various components function in order to bring you uniquely engineered products that are optimized for your patients. Click images to enlarge.
Exosome Characterization
Hilltop Bio is working with esteemed universities in order to:
- Further understand the role that exosomes play and how to characterize them appropriately
- Provide you, the veterinarian, with cutting edge research and products
Learn more about Exosomes in this JAVMA Article
Left: Sample exosome particle count
Right: Fluorescent view of tagged exosomes
IL-1ra Characterization
Hilltop Bio characterizes every lot produced and guarantees that it meets our strict standards. This is one example of how the concentration of one protein, IL-1ra, within our products compares to older products that are still on the market. This is a comparatively high concentration, and our products consistently meet these parameters.
Nuclear Scintigraphy
Evidence of Exosome Dispersion
Hilltop Bio worked with Animal Imaging in Texas to radio-label the exosomes present in our products. The radio-labeled product was administered via regional limb perfusion, and then images were taken at three intervals: during perfusion, immediately after, and then 30 minutes after (shown at left).
Proteomic Analysis
We partner with respected universities to analyze and characterize the 1200+ proteins within our products to better understand how they function both separately and together.
Resources
Scientific Articles
- Active Components in Hilltop Bio’s Products
- Lyophilization of Biopharmaceuticals
- Regenerative Medicine 2.0 [JAVMA]
Study Results
Useful Links
- Products: List of current products and those in development.
- Case Studies: Seeing is believing! Submitted by your peers.
- See what your peers are saying about our products.
- Check out our Video Gallery covering a range of topics.
- Continuing Education: Register for our upcoming events, including our monthly free RACE-approved webinars.
Complete list of scientific References