Regenaflex-K9
is anintra-muscular injectablethat provides unparalleled convenience to small- and mixed-animal veterinary practices.
The Hilltop Bio Difference
Compared to older orthobiologics like PRP or stem cells that are variable, labor-intensive, and require special equipment, our therapies are consistent dose-to-dose and are ready to use in under a minute!
Uses
- Non-healing wounds
- Lameness associated with soft tissue injury (tendon, ligament, muscle)
- Lameness secondary to osteoarthritis
Studies
- Osteoarthritis: Hilltop Bio recently completed a blinded study using Regenaflex-K9 for Canine Osteoarthritis. Preliminary data looks positive and we expect to publish results this fall.
- Safety Study – Regenaflex-K9 for Managing Canine Lameness
- Safety Study – Regenaflex (equine) Safety Study.
How Does Regenaflex-K9 Work?
Regenaflex-K9 contains growth factors, cytokines, and exosomes — factors demonstrated to stimulate healing by delivering a cell-signaling cascade to reduce inflammation, promote healing, and decrease scarring.
Case Study
Dr. Peggy Minnich | Aquia-Garrisonville Animal Hospital
Shiloh is a 125lb, 6yo neutered male shepherd
- Lame in the left front leg for about a year, receiving only joint supplements. Pain was localized to the shoulder joint at the insertion point of the biceps tendon.
IMAGING: No bony abnormalities were noted.
TREATMENT: Shock Wave therapy was administered on the joint, resulting in about 70% improvement. Shiloh then received one 1ml dose of Regenaflex-K9.
RESULTS: 2 weeks after this injection, he was 100% sound.
References:
- Dinarello CA. Historical review of cytokines. Eur J Immunol 2007;37(Suppl1):S35-S45.
- Gelhorn A and Han A. The use of dehydrated human amnion/chorion membrane allograft injection for the treatment of tendinopathy or arthritis: A case series involving 40 patients. P M & R 2017;9:1236-1243.
- Gulati K, Guhathakurta S, Joshi J, et al. Cytokines and their role in health and disease: a brief overview. MOJ Immunol 2016;4(2):00121.
- Gupta A. Allogenic Amniotic Tissue for Treatment of Knee and Hip Osteoarthritis. Pharmaceuticals (Basel). 2022 Mar 26;15(4):404.
- Kimmerling, K.A., Gomoll, A.H., Farr, J. et al. Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model. Arthritis Res Ther 24, 63 (2022).
- Shimberg, M. The use of amniotic-fluid concentrate in orthopedic conditions. Journal of Bone and Joint Surgery, Vol. 20 No. 1, January 1938.
- Werber, B. Amniotic tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis. Journal of Sports Medicine 215, 219896, 2015.
- Williams, K. B., & Ehrhart, N. P. Regenerative medicine 2.0: extracellular vesicle–based therapeutics for musculoskeletal tissue regeneration. JAVMA, 2022; 260(7), 683-689.