Regenaflex-RT 

is specifically formulatedfor soft tissue and contains bioscaffold material to aid the integration of healing tissue with the surrounding healthy tissue.

The Hilltop Bio Difference

Compared to older orthobiologics like PRP or stem cells that are variable, labor-intensive, and require special equipment, our therapies are consistent dose-to-dose and are ready to use in under a minute, with no processing, no thawing, and no equipment!

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One-Step Prep: Ready to use in under a minute
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No Variability: Consistent formulation delivers reliable results
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100% Natural: Humanely sourced Birth tissues
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Save Time & Money: no equipment or processing required
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Off-the-Shelf: Long-term, room temperature storage
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Quality: Manufactured under strict cGMP/cGTP guidelines

Indications

  • Tendon, ligament and muscle injuries
  • Non-healing wounds
  • Lower Limb/Foot via Regional Limb Perfusion

Administration

  • Intralesional Injection
  • Periligamentous Injection
  • Peritendonous Injection
  • Regional Limb Perfusion

How Does Regenaflex-RT Work?

Regenaflex-RT contains cytokines, growth factors and exosomes— factors demonstrated to stimulate healing by delivering a cell-signaling cascade to reduce inflammation, promote healing, and decrease scarring.

Studies

Case Study

Dr. Tim Ober  | John R. Steele & Associates

9 years old KWPN Mare, jumper, last shown in 1.15m

Pulled shoe LF in the paddock on 7/10/2021. Both clips in her foot and walking lame. Client packed the foot and treated with Bute. While improved, she remained lame at the trot. The LF and LH swelled within two days, appearing like cellulitis. The swelling had been steadily improving.

First Exam: 7/17/2021

  • Walking sound but 2/5 LF at the trot. No elevated pulse. LF and LH limbs swollen with what appeared to be cellulitis but had steadily improved.

Second Exam: 7/19/2021

  • Mild swelling of the LF mid tendon area persists. No heat or pain on palpation. LF lame 1/5 in a straight line and on a circle. Under tack 3+/5 on the circle to the right, slightly better to the left but significantly more lame under tack than in hand. Diagnostic block LF high PDN positive, significantly better to the right but still some lameness to the left.

Ultrasound Exam: LF Inferior Check Ligament Desmitis

TREATMENT

7/22/21: LF carpal sheath was injected with Hyaluronate and Triamcinalone. After treating the carpal sheath the leg looked better for a week then started swelling again.

8/10/21: Recheck ultrasound showed LF ICL desmitis to be more significant than at first exam, with heat and soreness on palpation. Treatment options were discussed.

8/27/21: Treatment: Ultrasound guided injection LF ICL with Regenaflex.

8/29/21: Bandage was removed, the LF leg was about 50% smaller than before the injection of the ICL. No heat or pain on palpation.Follow up ultrasound on 9/16/21 showed significant improvement.

IMAGES: Left: 8/10/2021 before treatment. Right: 9/16/2021 after treatment.

View additional Case Studies.

References:

  1. Dinarello CA. Historical review of cytokines. Eur J Immunol 2007;37(Suppl1):S35-S45.
  2. Gelhorn A and Han A. The use of dehydrated human amnion/chorion membrane allograft injection for the treatment of tendinopathy or arthritis: A case series involving 40 patients. P M & R 2017;9:1236-1243.
  3. Gulati K, Guhathakurta S, Joshi J, et al. Cytokines and their role in health and disease: a brief overview. MOJ Immunol 2016;4(2):00121.
  4. Lange-Consiglio A, Tassan S, Corradetti B, Meucci A, Perego R, Bizzaro D, Cremonesi F. Investigating the efficacy of amnion-derived compared with bone-marrow-derived mesenchymal stromal cells in equine tendon and ligament injuries. Cytotherapy, 2013; 0, 1-10.
  5. OrthoInfo. Helping Fractures Heal (Orthobiologics). January 2010. Available at: https://orthoinfo.aaos.org/en/treatment/helping-fractures-heal-orthobiologics/
  6. Shimberg, M. The use of amniotic-fluid concentrate in orthopedic conditions. Journal of Bone and Joint Surgery, Vol. 20 No. 1, January 1938. 
  7. Werber, B. Amniotic tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis. Journal of Sports Medicine 215, 219896, 2015.
  8. Williams, K. B., & Ehrhart, N. P. Regenerative medicine 2.0: extracellular vesicle–based therapeutics for musculoskeletal tissue regeneration. JAVMA, 2022; 260(7), 683-689.