Wound Healing Factors of Exosome Therapies

Let’s face it. If you’re involved in horses in any way, you know that sooner or later, they will find a way to injure themselves. It’s not a matter of “if,” but “when.” Over the years, veterinarians have had many ways to treat injuries ranging from minor scratches to potentially life-threatening wounds. However, one of the latest treatments that has been garnering more attention in recent years is the realm of regenerative treatments, and in this case, exosome therapies.

What is Regenaflex-M and how can it help a wound heal?
Regenaflex-M is a membrane that contains a cocktail of powerhouse components like extracellular vesicles, growth factors, exosomes, cytokines, microRNA, and extracellular matrix. According to literature, these components help in up-regulating a horse’s own immune response that aids tissue healing. Within the membrane, the cells release products from the extracellular matrix that increase the levels of growth factors that help stimulate healing. Also present within the extracellular matrix are collagen substrates which provide a “scaffold” to rebuild new tissue. There isn’t just one factor at work but several including anti-inflammatory, anti-microbial, anti-fibrotic, and anti-adhesion properties.

“There are a lot of positive growth factors and anti-inflammatory factors that are present within Regenaflex-M membrane allografts,” Dr. David Dutton explains. “It has anti-microbial properties, and we’ve seen there are also factors that decrease adhesion formation, fibrosis, and ultimately, scarring.”

Two unique factors of Hilltop Bio’s therapies are that they can be stored at room temperature for up to a year, and they are available off the shelf with no additional preparation or equipment needed. In situations where time is of the essence, this means one step closer to implementation and getting healing underway. Also, unless it’s a large external wound, many cases only require one treatment which makes it easier on the veterinarian, patient, and horse owner.

“As the tissue heals from an injury, we tend to get a monolayer of healing,” he continues. “However, with the membrane’s components, we can start to see an increase in healing through tissue layering. We’ve seen more of the normal layers come back.”

Ready to add Hilltop Bio’s membrane and injectable therapies to your veterinary toolkit? Are you a current Hilltop Bio user and want to share some case studies? Reach out and let us know how we can help.